MOTS-c in context
MOTS-c is described in the literature as a mitochondria-derived peptide associated with retrograde signaling and metabolic or stress-response pathways. Reviews and primary studies span cellular, animal, and mechanistic work. The existence of a published effect in a model does not establish a human therapeutic conclusion.
Read the evidence by model
When reviewing a MOTS-c paper, note the species, tissue, delivery route, exposure, endpoint, and comparator. Reviews are useful maps, while primary studies carry the details needed to judge whether a result is relevant to a proposed laboratory experiment.
Connect literature to the record
The MOTS-c product record and any supplier COA address the material supplied under a particular lot. The literature addresses a research question under a particular model. Keep those evidence types linked but not blended.
Sources and further reading
- MOTS-c: A Promising Mitochondrial-Derived Peptide for Metabolic Regulation ↗Review-level overview of MOTS-c biology and metabolic research.
- MOTS-c, the Most Recent Mitochondrial Derived Peptide in the Regulation of Metabolism ↗Review of mechanisms and model systems.
- The Mitochondria-Derived Peptide MOTS-c Promotes Metabolic Homeostasis ↗Primary preclinical study; interpret within its model and limitations.